Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease

Jemma G. Kerns; Panagiotis D. Gikas; Kevin Buckley; Adam Shepperd; Helen L. Birch; Ian McCarthy; Jonathan Miles; Timothy W. R. Briggs; Richard Keen; Anthony W. Parker; Pavel Matousek; Allen E. Goodship

doi:10.1002/art.38360

Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease

Jemma G. Kerns, Panagiotis D. Gikas, Kevin Buckley, Adam Shepperd, Helen L. Birch, Ian McCarthy, Jonathan Miles, Timothy W. R. Briggs, Richard Keen, Anthony W. Parker, Pavel Matousek, Allen E. Goodship

Centre for Ageing Research

Research output: Contribution to Journal/Magazine › Journal article › peer-review

24 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

Original language	English
Pages (from-to)	1237-1246
Number of pages	10
Journal	Arthritis and Rheumatology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1002/art.38360
Publication status	Published - 05/2014

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10.1002/art.38360

http://onlinelibrary.wiley.com/doi/10.1002/art.38360/abstract;jsessionid=D26CAE5B5BF0FCB40ED624CC33B3B988.f04t04

Health Business Awards
Kerns, J. (Participant)
Impact: Other Impacts
New bone diagnostic tool development
Kerns, J. (Participant)
Impact

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Kerns, J. G., Gikas, P. D., Buckley, K., Shepperd, A., Birch, H. L., McCarthy, I., Miles, J., Briggs, T. W. R., Keen, R., Parker, A. W., Matousek, P., & Goodship, A. E. (2014). Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease. Arthritis and Rheumatology, 66(5), 1237-1246. https://doi.org/10.1002/art.38360

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title = "Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease",

abstract = "Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.",

author = "Kerns, {Jemma G.} and Gikas, {Panagiotis D.} and Kevin Buckley and Adam Shepperd and Birch, {Helen L.} and Ian McCarthy and Jonathan Miles and Briggs, {Timothy W. R.} and Richard Keen and Parker, {Anthony W.} and Pavel Matousek and Goodship, {Allen E.}",

note = "{\textcopyright} 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.",

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AU - Kerns, Jemma G.

AU - Gikas, Panagiotis D.

AU - Buckley, Kevin

AU - Shepperd, Adam

AU - Birch, Helen L.

AU - McCarthy, Ian

AU - Miles, Jonathan

AU - Briggs, Timothy W. R.

AU - Keen, Richard

AU - Parker, Anthony W.

AU - Matousek, Pavel

AU - Goodship, Allen E.

PY - 2014/5

Y1 - 2014/5

N2 - Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

AB - Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

U2 - 10.1002/art.38360

DO - 10.1002/art.38360

M3 - Journal article

C2 - 24470432

SN - 2326-5191

VL - 66

SP - 1237

EP - 1246

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

IS - 5

ER -

Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease

Abstract

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Impacts

Health Business Awards

New bone diagnostic tool development

Cite this