Projects per year
Personal profile
SUMMARY of research interests (100 words)
My laboratory focuses on 'Local immune responses' that occur within the thoracic cavity. In particular the interaction of the macrophages of the pleural cavity and fat associated lymphoid clusters of the pericardium and mediastinum. Inflammation of the pleural space induces the production of innate IgM from B cells residing in FALCs, and causes fluid phase macrophages to divide locally, however it is unclear how these two responses are interlinked. We are working to uncover the mechanism by which macrophages detect IgM, in the context of allergic airway inflammation, parasite infection and cancer.
Related documents
Education/Academic qualification
The Alternative Activation of Dendritic Cells (PhD), University of Edinburgh
Award Date: 17/12/2012
Keywords
- Biomedical and life sciences
- Immunology
- Inflammation
- Infection
- Macrophage
- IgM
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A comprehensive study of dysfunctional HDL to identify markers for cardiovascular disease status and risk
Jackson-Jones, L. (Co-Investigator), Middleton, D. (Principal Investigator) & Allinson, S. (Co-Investigator)
1/12/23 → 30/11/26
Project: Research
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REMIT: Reconstructing the In Vivo Evolution of Mesothelioma for Improved Therapy
Jackson-Jones, L. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research
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Mesothelioma Disease Evolution (CRUK Discovery Award supplement - REMIT)
Jackson-Jones, L. (Principal Investigator)
1/02/23 → 31/01/24
Project: Research
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Tropism, Immunity and Pathology in African sleeping sickness (HAT-TIP)
Worthington, J. (Co-Investigator), Dawson, N. (Co-Investigator), Urbaniak, M. (Principal Investigator) & Jackson-Jones, L. (Co-Investigator)
The Dowager Countess Eleanor Peel Trust
1/01/22 → 30/09/22
Project: Research
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Local oxidised phospholipids within the pleural cavity: fuelling macrophage response during inflammation?
Jackson-Jones, L. (Principal Investigator)
1/10/21 → 30/09/24
Project: Research
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Stromal cells covering omental fat-associated lymphoid clusters trigger the formation of neutrophil aggregates to capture peritoneal contaminants
Jackson-Jones, L., Smith, P., Portman, J., Magalhaes, M. S., Mylonas, K., Vermeren, M., Nixon, M., Henderson, B., Dobie, R., Vermeren, S., Denby, L., Henderson, N., Mole, D. & Bénézech, C., 14/04/2020, In: Immunity. 52, 4, p. 700-715 16 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open AccessFile22 Citations (Scopus)285 Downloads (Pure) -
FALC stromal cells define a unique immunological niche for the surveillance of serous cavities
Jackson-Jones, L. & Benezech, C., 1/06/2020, In: Current opinion in immunology. 64, p. 42-49 8 p.Research output: Contribution to Journal/Magazine › Review article › peer-review
Open AccessFile4 Citations (Scopus)286 Downloads (Pure) -
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
Jackson-Jones, L. H., Duncan, S. M., Magalhaes, M. S., Campbell, S. M., Maizels, R. M., McSorley, H. J., Allen, J. E. & Bénézech, C., 1/09/2016, In: Nature Communications. 7, 14 p., 12651.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access55 Citations (Scopus) -
Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C. M., Jackson-Jones, L. H., García-Fojeda, B., Knipper, J. A., Sutherland, T. E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D. A., Artigas, A., Stamme, C., Chroneos, Z. C., Zaiss, D. M., Casals, C. & Allen, J. E., 9/06/2017, In: Science. 356, 6342, p. 1076-1080 5 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open AccessFile105 Citations (Scopus)892 Downloads (Pure) -
IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L. H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R. M., Sutherland, T. E., Jenkins, S. J., McSorley, H. J., Bénézech, C., MacDonald, A. S. & Allen, J. E., 10/2016, In: European Journal of Immunology. 46, 10, p. 2311-2321 11 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access25 Citations (Scopus)
Activities
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UlverSTEM 2025
Allinson, S. (Organiser) & Jackson-Jones, L. (Organiser)
15/11/2025Activity: Other activity types › Types of Public engagement and outreach - Festival/Exhibition
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Co-ordinating Immunity within the pleural space
Jackson-Jones, L. (Speaker)
23/10/2025 → 24/10/2025Activity: Talk or presentation types › Invited talk
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38th European Macrophage and Dendritic Cell Society Meeting 2025
Jackson-Jones, L. (Chair)
16/09/2025 → 18/09/2025Activity: Participating in or organising an event types › Participation in conference - Academic
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BSI (Publisher)
Jackson-Jones, L. (Editorial board member)
07/2025 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Windermere Science Festival 2025
Jackson-Jones, L. (Organiser), Allinson, S. (Organiser), Wright, K. (Speaker), Hall, S. (Speaker) & Leeman, J. (Speaker)
10/05/2025Activity: Other activity types › Types of Public engagement and outreach - Festival/Exhibition