Projects per year
Personal profile
Research Interests
My research focuses on understanding the aetiology of Alzheimer's disease (AD). In particular, I focus on the development of cerebral amyloid angiopathy (CAA), the deposition of toxic β-amyloid proteins in the walls of the blood vessels of the AD brain. I am interested in how risk factors for AD, such as ageing and obesity, affect the structure of the blood vessels and their ability to remove β-amyloid from the brain.
I am also interested in how the early life environment, including maternal and paternal obesity, impacts on the health and function of the offspring brain and if the early life environment predisposes individuals towards developing age-related diseases like AD.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A2bAD: Targeting the astrocyte adenosine 2b receptor for improved vascular function in Alzheimer's Disease
Hawkes, C. (Co-Investigator), Theparambil, S. (Principal Investigator) & Dawson, N. (Co-Investigator)
1/10/25 → 30/09/29
Project: Research
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Investigating astroglial bicarbonate transport in stroke-induced pH imbalance and injury in the brain
Theparambil, S. (Principal Investigator) & Hawkes, C. (Co-Investigator)
1/12/24 → 31/10/26
Project: Research
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Impact of paternal obesity on offspring brain structure and function; implications for Alzheimer's disease
Hawkes, C. (Principal Investigator) & Dawson, N. (Co-Investigator)
1/01/23 → 31/12/27
Project: Research
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Characterisation of perivascular astrocyte heterogeneity in human brains
Hawkes, C. (Principal Investigator)
1/01/22 → 31/12/23
Project: Research
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The role of soluble APP fragments in Alzheimer's disease
Parkin, E. (Principal Investigator), Dawson, N. (Principal Investigator) & Hawkes, C. (Principal Investigator)
1/10/21 → 30/09/25
Project: Research
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A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring
Chadwick, H., Junior, V., Dawson, N. & Hawkes, C., 31/05/2026, In: Obesity Reviews. 27, 5, e70067.Research output: Contribution to Journal/Magazine › Review article › peer-review
Open AccessFile3 Downloads (Pure) -
EZH2 inhibition enhances the activity of Carboplatin in aggressive-variant prostate cancer cell lines
Latarani, M., Pucci, P., Eccleston, M., Manzo, M., Gangadharannambiar, P., Fischetti, I., Alborelli, I., Mongiardini, V., Mahmood, N., Colombo, M. P., Grimaldi, B., Rigas, S., Akamatsu, S., Hawkes, C., Wang, Y., Jachetti, E. & Crea, F., 28/02/2025, In: Epigenomics. 17, 3, p. 145-154 10 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice
Contu, L., Johnson, A., Heath, C. J. & Hawkes, C. A., 30/11/2025, In: Aging Cell. 24, 11, 13 p., e70223.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring
Holt, D., Contu, L., Wood, A., Chadwick, H., Alborelli, I., Insilla, A. C., Crea, F. & Hawkes, C. A., 22/08/2024, In: Nutrients. 16, 16, 2805.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy
Kelly, L., Brown, C., Michalik, D., Hawkes, C. A., Aldea, R., Agarwal, N., Salib, R., Alzetani, A., Ethell, D. W., Counts, S. E., de Leon, M., Fossati, S., Koronyo‐Hamaoui, M., Piazza, F., Rich, S. A., Wolters, F. J., Snyder, H., Ismail, O., Elahi, F. & Proulx, S. T. & 6 others, , 21/02/2024, In: Alzheimer's and Dementia : the journal of the Alzheimer's Association. 20, 2, p. 1421-1435Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access
Activities
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546.8 mL of Science
Hawkes, C. (Speaker), Martin, J. (Organiser), Brand, A. (Speaker) & Lovell, D. (Speaker)
28/07/2026Activity: Talk or presentation types › Public Lecture/ Debate/Seminar
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NeuRAL Network Research Seminar
Dalton, B. (Speaker), Jeantils, C. (Speaker), Hawkes, C. (Organiser) & Dawson, N. (Organiser)
29/05/2026Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Campus in the City 2026
Hammond, J. (Organiser), Hall, S. (Participant), Hawkes, C. (Participant), Rojas Martinez, F. (Participant), Shih, B. (Contributor), Menzies, S. (Contributor) & Allinson, S. (Contributor)
10/04/2026Activity: Participating in or organising an event types › Festival/Exhibition/Concert
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ARUK Northwest seminar
Hawkes, C. (Speaker)
10/11/2025Activity: Talk or presentation types › Oral presentation
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Does Alzheimer's disease start in utero
Hawkes, C. (Speaker)
10/11/2025Activity: Talk or presentation types › Invited talk
Press/Media
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Intergenerational effects of maternal obesity on long-term health of offspring
11/12/19
1 Media contribution
Press/Media: Other
Datasets
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Additional file 1 of α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A. (Creator), Heath, C. J. (Creator), Sharp, M. M. (Creator), Górecki, D. C. (Creator) & Carare, R. O. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20762858.v1, https://springernature.figshare.com/articles/figure/Additional_file_1_of_-Dystrobrevin_knockout_mice_have_increased_motivation_for_appetitive_reward_and_altered_brain_cannabinoid_receptor_1_expression/20762858/1
Dataset
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Additional file 2 of α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A. (Creator), Heath, C. J. (Creator), Sharp, M. M. (Creator), Górecki, D. C. (Creator) & Carare, R. O. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20762861.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_-Dystrobrevin_knockout_mice_have_increased_motivation_for_appetitive_reward_and_altered_brain_cannabinoid_receptor_1_expression/20762861/1
Dataset
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α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A. (Creator), Heath, C. J. (Creator), Sharp, M. M. (Creator), Górecki, D. C. (Creator) & Carare, R. O. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.6176087.v1, https://springernature.figshare.com/collections/_-Dystrobrevin_knockout_mice_have_increased_motivation_for_appetitive_reward_and_altered_brain_cannabinoid_receptor_1_expression/6176087/1
Dataset
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Volinanserin impact on behaviour and brain metabolism
Bryers, A. (Creator), Dawson, N. (Creator), Parkin, E. (Contributor) & Hawkes, C. (Contributor), Lancaster University, 10/07/2026
DOI: 10.17635/lancaster/researchdata/750
Dataset