Projects per year
Personal profile
SUMMARY of research interests (100 words)
Respiratory pathogens must interact with and negotiate colonisation of the specialised epithelial cells that line the nose. These cells form a protective barrier and contact with pathogens triggers immune responses that lead to production of protective immunity. This process changes with age, environmental factors, and the respiratory microbiome. We use state-of-the-art models and advanced imaging technology to study how interactions of bacteria such as Streptococcus pneumoniae affect the respiratory epithelium.
Current Teaching
BIOL112 - Cell Structure and Function (Module Organiser)
BIOL243 - Medical Microbiology
BIOL334 - New and Emerging Microbial Pathogens
BIOL387(a) - Literature Review and Research Project
BIOL444 - Models of Disease
BIOL469 - MSci Literature Review and Research Project
My Role
Early Career Researcher Training Tutor for BLS
External Roles
ECR Editorial Board Member for Immunotherapy Advances
Co-lead on Respiratory Working Group for ICCARP
Education/Academic qualification
Fellow of the Higher Education Academy
Award Date: 1/02/2019
PhD, Infection mechanisms of Toxoplasma gondii in the small intestine, University of East Anglia
External positions
ECR Editorial Board Committee Member, Immunotherapy Advances Journal
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
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Development of advanced technologies to study pneumococcal infection in the human respiratory epithelium
Weight, C. (Principal Investigator)
31/03/25 → 30/03/27
Project: Research
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C-Trap for the North West: Visualization of single moleculebiomolecular dynamics for the biosciences.
Parry, J. (Co-Investigator), Benedetto, A. (Co-Investigator), Kotsantis, P. (Co-Investigator), Gatsiou, A. (Co-Investigator), Hardy, J. (Co-Investigator), Unterholzner, L. (Co-Investigator), Weight, C. (Co-Investigator), Robinson, N. (Principal Investigator), Fletcher, N. (Co-Investigator), Copeland, N. (Co-Investigator), Urbaniak, M. (Co-Investigator), Carmo-Silva, E. (Co-Investigator), Orr, D. (Co-Investigator) & Mort, R. (Co-Investigator)
1/08/25 → 31/07/26
Project: Research
Research output
- 5 Journal article
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Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
International Consortium for the Classification of Ageing-Related Pathologies (ICCARP), Short, E., Calimport, S. & Bentley, B., 30/04/2025, In: GeroScience. 47, 2, p. 1713-1720 8 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open AccessFile66 Downloads (Pure) -
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections
Rosenheim, J. & Weight, C., 31/12/2024, In: Nature Communications. 15, 13 p., 10434.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae
Chan, J. M., Ramos-Sevillano, E., Betts, M., Wilson, H. U., Weight, C., Houhou-Ousalah, A., Pollara, G., Brown, J. S. & Heyderman, R. S., 7/05/2024, In: Infection and Immunity. 92, 5, e00447-23.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open AccessFile29 Downloads (Pure) -
A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge
Hill, H., Mitsi, E., Nikolaou, E., Blizard, A., Pojar, S., Howard, A., Hyder-Wright, A., Devin, J., Reiné, J., Robinson, R., Solórzano, C., Jochems, S. P., Kenny-Nyazika, T., Ramos-Sevillano, E., Weight, C. M., Myerscough, C., McLenaghan, D., Morton, B., Gibbons, E. & Farrar, M. & 10 others, , 15/10/2023, In: American Journal of Respiratory and Critical Care Medicine. 208, 8, p. 868-878 11 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Obolski, U., Swarthout, T. D., Kalizang’oma, A., Mwalukomo, T. S., Chan, J. M., Weight, C. M., Brown, C., Cave, R., Cornick, J., Kamng’ona, A. W., Msefula, J., Ercoli, G., Brown, J. S., Lourenço, J., Maiden, M. C., French, N., Gupta, S. & Heyderman, R. S., 17/11/2023, In: Nature Communications. 14, 1, 7477.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access
Activities
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Advancing technologies and physiologically relevant cell culture models to study complex human respiratory infections
Weight, C. (Speaker)
08/2024Activity: Talk or presentation types › Invited talk
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Nature Communications (Journal)
Weight, C. (Peer reviewer)
31/08/2025Activity: Publication peer-review and editorial work types › Editorial activity
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Effects of Air Particulate Matter on Susceptibility to Respiratory Infection
Weight, C. (Speaker)
23/07/2025Activity: Talk or presentation types › Invited talk
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Factors Affecting Respiratory Responses to Infection
Weight, C. (Speaker)
7/07/2025Activity: Talk or presentation types › Invited talk
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ECRs Networking Consortium
Weight, C. (Speaker)
25/06/2025Activity: Participating in or organising an event types › Participation in workshop, seminar, course