Projects per year
Personal profile
SUMMARY of research interests (100 words)
Our lab is passionate about exploring RNA's diverse roles in regulating fundamental biological processes. We focus on how intrinsic RNA traits influence key mechanisms, such as gene expression, and systems like the body’s defense mechanisms, termed " immunity ", essential for life. Leveraging cutting-edge technologies, including next-generation sequencing, genome editing, and in-house tool development, we aim to uncover RNA’s molecular dynamics in detail. Our interdisciplinary approach bridges molecular/RNA biology, biotechnology, and computational science, incorporating physics and math to push the boundaries of RNA research. Ultimately, our goal is to apply this knowledge to precision medicine, advancing RNA-based diagnostics and therapeutics for treating immune-associated diseases.
Current Research
My current research is funded by BBSRC and the Lancaster University Faculty of Health & Medicine, and focuses on:
a) developing tools suitable to infer RNA dynamics at single-nucleotide resolution in human cells.
b) exploring cell intrinsic RNA dynamics in relation to our inherent body's defense system, called " innate immunity ".
Current Teaching
I teach RNA regulation contributing to Genetics BIOL253/311 module.
I undertake the supervision of undergraduate and post-graduate research students contributing to BIOL387/a and BIOL469/470 modules.
User-defined keywords
- RNA
- RNA Modifications
- RNA Editing
- Immunity
- Immunology
- Blood Vessels
- Gene expression
- Inflammation
- Next Generation Sequencing
- Multi-Omics
- RNA Structure
- Human Biology
- Immune Diseases
- Synthetic Immunology
- Cell function
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DSI: Towards understanding the RNA principles of innate immunity
Gatsiou, A. (Principal Investigator)
The Academy of Medical Sciences
1/08/25 → 31/07/27
Project: Research
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Investigate the gene expression changes in atopic dermatitis-like skin inflammation and its resolution
Shih, B. (Principal Investigator), Saunders, A. (Principal Investigator) & Gatsiou, A. (Co-Investigator)
Project: Research
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C-Trap for the North West: Visualization of single moleculebiomolecular dynamics for the biosciences.
Parry, J. (Co-Investigator), Benedetto, A. (Co-Investigator), Kotsantis, P. (Co-Investigator), Gatsiou, A. (Co-Investigator), Hardy, J. (Co-Investigator), Unterholzner, L. (Co-Investigator), Weight, C. (Co-Investigator), Robinson, N. (Principal Investigator), Fletcher, N. (Co-Investigator), Copeland, N. (Co-Investigator), Urbaniak, M. (Co-Investigator), Carmo-Silva, E. (Co-Investigator), Orr, D. (Co-Investigator) & Mort, R. (Co-Investigator)
1/08/25 → 31/07/26
Project: Research
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RNA modifications in cardiovascular health and disease
Gatsiou, A. & Stellos, K., 31/05/2023, In: Nature Reviews Cardiology. 20, 5, p. 325-346 22 p.Research output: Contribution to Journal/Magazine › Review article › peer-review
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
Gatsiou, A., Tual-Chalot, S., Napoli, M., Ortega-Gomez, A., Regen, T., Badolia, R., Cesarini, V., Garcia-Gonzalez, C., Chevre, R., Ciliberti, G., Silvestre-Roig, C., Martini, M., Hoffmann, J., Hamouche, R., Visker, J. R., Diakos, N., Wietelmann, A., Silvestris, D. A., Georgiopoulos, G. & Moshfegh, A. & 18 others, , 9/05/2023, In: Immunity. 56, 5, p. 979-997.e11 19 p.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
RNA Editing Therapeutics: Advances, Challenges and Perspectives on Combating Heart Disease
Birgaoanu, M., Sachse, M. & Gatsiou, A., 30/04/2023, In: Cardiovascular Drugs and Therapy. 37, 2, p. 401-411 11 p.Research output: Contribution to Journal/Magazine › Review article › peer-review
Open Access -
Ticagrelor Induces Angiogenesis in Progenitor and Mature Endothelial Cells In Vitro: Investigation of the Possible Role of Adenosine
Sidiropoulou, S., Gatsiou, A., Hansson, K. M., Tsouka, A. N., Stellos, K. & Tselepis, A. D., 12/12/2024, In: International Journal of Molecular Sciences. 25, 24, 13343.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access -
Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction
Sopova, K., Tual-Chalot, S., Mueller-Hennessen, M., Vlachogiannis, N. I., Georgiopoulos, G., Biener, M., Sachse, M., Turchinovich, A., Polycarpou-Schwarz, M., Spray, L., Maneta, E., Bennaceur, K., Mohammad, A., Richardson, G. D., Gatsiou, A., Langer, H. F., Frey, N., Stamatelopoulos, K., Heineke, J. & Duerschmied, D. & 3 others, , 22/06/2023, In: Frontiers in Immunology. 14, 1177467.Research output: Contribution to Journal/Magazine › Journal article › peer-review
Open Access
Activities
- 1 School Engagement
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In2STEM
Kotsantis, P. (Host), Shih, B. (Host), Gatsiou, A. (Host), Hammond, J. (Host) & Hannan, S. (Speaker)
20/07/2026 → 24/07/2026Activity: Business or School/HEI Engagement › School Engagement